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Mechanistic aspects of COX-2 expression in colorectal neoplasia -- Mode of action of aspirin as a chemopreventive agent -- Coxibs: pharmacology, toxicity and efficacy in cancer clinical trials -- COX-2 active agents in the chemoprevention of colorectal cancer -- New NSAID targets and derivatives for colorectal cancer chemoprevention -- Aspirin in prevention of sporadic colorectal cancer: current clinical evidence and overall balance of risks and benefits -- Nutritional agents with anti-inflammatory properties in chemoprevention of colorectal neoplasia -- Genetics, inheritance and strategies for prevention in populations at high risk of colorectal cancer (CRC).