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Author Nazemzadeh, Sima, author.
Title Regulation of PPAR-[delta] target genes by GW501516 in HepG2 cells / by Sima Nazemzadeh.
Published [Northridge, California] : California State University, Northridge, 2012.
LOCATION CALL # STATUS
 Electronic Book  QD40 .Z952 2012 N39eb    ONLINE
  
Description 1 online resource (xiii, 78 pages) : illustrations, color.
Content Type text
still image
Format online resource
File Characteristics text file PDF
Thesis M.S. California State University, Northridge 2012.
Bibliography Includes bibliographical references (pages 73-78).
Note Description based on online resource; title from PDF title page (viewed on August 27, 2012).
Summary PPAR-[delta] was activated with GW501516 in HepG2 cells and the gene transcripts and protein expression of ACC2, CPTI and LPL were quantified with end-point PCR, real-time Q-PCR and Western blot. The gene expression of CPTI was also analyzed in rat L6 skeletal muscle cells. It was observed that activation of PPAR-[delta] with an agonist reduces fatty acid synthesis and enhances genes involved in fatty acid oxidation in the liver. This therefore suggests a switch from a fat-storing pathway to a fat-burning pathway in the liver and a switch of fatty acid oxidation from skeletal muscle cells to liver cells for energy supply.
Subject Nuclear receptors (Biochemistry)
Ligands (Biochemistry)
Fatty acids -- Research.
Local Subject Dissertations, Academic -- CSUN -- Chemistry and Biochemistry -- Biochemistry.
OCLC number 847744317